Abstract: Objective: To clarify the correlation between the severity of pemphigus and depression, anxiety, and quality of life. Methods: Pemphigus patients in the department of dermatology from August 2024 to February 2025 were selected. The Beck Depression Inventory-II (BDI-II), Beck Anxiety Inventory (BAI), and Dermatology Life Quality Index (DLQI) were used to assess depression, anxiety, and quality of life, respectively. The Pemphigus Disease Area Index (PDAI) was recorded. Healthy individuals during the same period served as the control group. Results: A total of 104 pemphigus patients and 62 healthy controls were included. The scores of BDI-II, BAI, and DLQI in the patient group were significantly higher than those in the control group (Ps＜ 0.05). PDAI was weakly positively correlated with BDI-II (r = 0.277) and BAI (r=0.201), and moderately positively correlated with DLQI (r = 0.401) (Ps＜ 0.05). Strong positive correlations were observed between BDI-II, BAI, and DLQI (r≥0.621, P＜0.01). Regression analysis showed that PDAI had a significant positive impact on BDI-II, BAI, and DLQI (Ps＜0.05). Conclusion: Pemphigus patients exhibit higher levels of depression and anxiety, as well as poorer quality of life, all of which are positively correlated with disease severity. Clinical attention should be paid to mental health and corresponding interventions should be provided to improve prognosis.

Key words: pemphigus, disease severity, depression, anxiety, quality of life