Abstract: Objective: To assess the efficacy of NB-UVB combined with 8-MOP PUVA in the treatment of psoriasis vulgaris on lower legs. Methods: The PASI of lesions on lower legs of 16 patients was assessed. One side of the lower legs of the patients was treated with NB-UVB and another side was treated with NB-UVB combined with PUVA, three times a week, 20 times totally. Results: The PASI of the lesions treated with NB-UVB before and after treatment were 8.21±2.97 and 2.31±1.01, with significant difference (P＜0.05) and the lesion treated with NB-UVB combined with PUVA were 8.33±2.54 and 1.20±0.93, with a significant difference (P＜0.05) . The PASI of the lesions treated with NB-UVB combined with PUVA was lower than that of the lesion treated with NB-UVB alone, with a significant difference (P＜0.05) . Conclusion: NB-UVB combined with PUVA is more effective than NB-UVB alone in the treatment of psoriatic plaque on legs.

Key words: NB-UVB, cream PUVA, psoriasis, plaque