中国麻风皮肤病杂志 ›› 2020, Vol. 36 ›› Issue (10): 621-625.doi: 10.12144/zgmfskin202010621

• 综述 • 上一篇    下一篇

氨苯砜在皮肤科的应用

赵晴,刘红,张福仁   

  1. 山东第一医科大学附属皮肤病医院（山东省皮肤病医院），山东省皮肤病性病防治研究所，济南，250022
  • 出版日期:2020-10-15 发布日期:2020-09-24
  • 通讯作者: 张福仁，E-mail: zhangfuren@hotmail.com

Dapsone in dermatology

ZHAO Qing, LIU Hong, ZHANG Furen   

  1. Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250022, China
  • Online:2020-10-15 Published:2020-09-24
  • Contact: ZHANG Furen, E-mail: zhangfuren@hotmail.com

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摘要： 氨苯砜（dapsone, DDS）曾被广泛应用于诸多感染性和炎症性皮肤病的治疗，但随着对其致死性药物不良反应-氨苯砜超敏反应综合征（dapsone hypersensitivity syndrome, DHS）的认识，DDS逐步退出临床，目前仅用于麻风的治疗。随着DHS风险因子HLA-B*13:01的发现和转化应用，DDS的应用前景一片光明。本文从DDS的药代学、药效学和就DDS在皮肤科应用做一综述。

关键词: 氨苯砜, 皮肤, 氨苯砜超敏反应综合征

Abstract: Dapsone (4,4-diaminodiphenylsulfone, DDS) was recommended as one of the drugs for treatment of infectious diseases and inflammatory diseases. However, a few of treated patients would suffer from a hypersensitivity syndrome after DDS therapy. The occurrence of dapsone hypersensitivity syndrome(DHS) limited the widespread clinical use of DDS and it was only used for treatment of leprosy. HLA-B*13:01 was reported as a strong risk factor for DHS and it has been found that prospective HLA-B*13:01 screening could prevent DHS. This allows for its use in dermatology. In this review, we discuss the pharmacokinetics, mechanisms of action, and indications of DDS.

Key words: dapsone, dermatology, dapsone hypersensitivity syndrome