中国麻风皮肤病杂志 ›› 2023, Vol. 39 ›› Issue (2): 86-88.doi: 10.12144/zgmfskin202302086

• 论著 • 上一篇    下一篇

浅层X线放射治疗29例顽固性寻常疣患者疗效评价

单晓峰,刘鑫洲,李建可,王秀环,刘国艳,张福仁   

  1. 山东第一医科大学附属皮肤病医院（山东省皮肤病医院），山东省皮肤病性病防治研究所，济南，250022
  • 出版日期:2023-02-15 发布日期:2022-12-27

Efficacy of superficial x-ray in the treatment of 29 patients with recalcitrant warts

SHAN Xiaofeng, LIU Xinzhou, LI Jianke, WANG Xiuhuan, LIU Guoyan, ZHANG Furen   

  1. Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250022, China
  • Online:2023-02-15 Published:2022-12-27

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摘要： 目的：评价浅层X射线治疗顽固性寻常疣的疗效和不良反应。方法：回顾性分析29例应用浅层X线照射治疗的顽固性寻常疣患者，治疗1~2次，第一次照射剂量8 Gy，4周后复诊，如皮疹仍然未愈，再次照射8 Gy。结果：29例患者共有54处皮疹，第一次治疗后，29处皮疹完全消退，疣体消退率53.7%，10例患者痊愈，痊愈率34.5%。第二次对17例患者的21处疣体进行治疗，14处疣体消退，消退率66.7%，11例患者痊愈，痊愈率64.7%。最终共有27例患者完成疗程，21例患者痊愈，痊愈率77.8%. 50处疣体，43处疣体消退，消退率86%。不良反应主要为一过性放射性皮炎，第一次和第二次治疗后分别有3例和5例发生，均在3个月内消失。结论：浅层X线放射对于顽固性寻常疣具有较好的疗效，为临床治疗提供了新的选择。

关键词: 浅层X线, 人类乳头瘤病毒, 疣

Abstract: Objective: To evaluate the efficacy of superficial X-ray in the treatment of refractory verruca vulgaris. Methods: 29 patients with refractory verruca vulgaris were treated with superficial X-ray irradiation, 1-2 times, the first dose of 8Gy, if the rash still did not heal 4 weeks later, then given the second X-ray irradiation with dose of 8Gy. Results: There were 54 rashes in 29 patients. After the first treatment, 29 rashes were completely resolved, with a regression rate of 53.7%. 10 patients were cured, with a recovery rate of 34.5%. After the second treatment, 14 of the 21 warts retreated, with a regression rate of 66.7%. Of the 17 patients, 11 were cured, with a recovery rate of 64.7%. In the end, 27 patients completed the whole observation, and 21 patients were cured, with a recovery rate of 77.8%. There were 50 warts in total, and 43 warts retreated, with a regression rate of 86%. The main adverse reactions were transient radiation dermatitis, which occurred in 3 cases after the first treatment and 5 cases after the second treatment, and disappeared within 3 months. Conclusion: Superficial X-ray radiation has a good effect on refractory viral wart, providing a new choice for treatment.

Key words: superficial X-ray, human papillomavirus, wart