中国麻风皮肤病杂志 ›› 2025, Vol. 41 ›› Issue (11): 826-828.doi: 10.12144/zgmfskin202511826

• 病例报告 • 上一篇    下一篇

甄氏外瓶霉致右手食指暗色丝孢霉病一例

曾茜1,汪礼强1,刘荣2,马玉帛3,郭艳阳3,付萌3   

  1. 1西安医学院，陕西西安，710021；2西安高新医院，陕西西安，710075；3空军军医大学西京皮肤医院，陕西西安，710032
  • 出版日期:2025-11-15 发布日期:2025-11-11

Cutaneous phaeohyphomycosis of the right index finger caused by Exophiala jeanselmei: a case report

ZENG Qian1, WANG Liqiang1, LIU Rong2, MA Yubo3, GUO Yanyang3, FU Meng3   

  1. 1 Xi'an Medical University, Xi'an 710021, China; 2 Xi'an Gaoxin Hospital, Xi'an 710075, China; 3 Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China
  • Online:2025-11-15 Published:2025-11-11

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摘要： 甄氏外瓶霉（Exophiala jeanselmei）是一种机会致病菌,常发生于免疫功能受损患者。本文报道1例免疫功能正常个体右手食指感染甄氏外瓶霉致的病例。患者，女，59岁。3个月前外伤后右手食指皮肤出现红色丘疹。组织病理示化脓型肉芽肿。PAS染色示真皮组织内串珠样菌丝结构。培养真菌经鉴定为甄氏外瓶霉。最终诊断为甄氏外瓶霉致皮肤暗色丝孢霉病。伊曲康唑联合手术切除治疗后痊愈。

关键词: 暗色丝孢霉病, 甄氏外瓶霉, 伊曲康唑

Abstract: Exophiala jeanselmei is an opportunistic pathogen that commonly occurs in immunocompromised patients. This report presents a case of Exophiala jeanselmei infection in the right index finger of an immunocompetent individual. The patient, a 59-year-old female, developed a red papule on the skin of her right index finger following trauma three months prior. Histopathological examination revealed a pyogenic granuloma. PAS staining demonstrated beaded hyphal structures within the dermal tissue. Fungal culture identified the pathogen as Exophiala jeanselmei. The diagnosis of cutaneous phaeohyphomycosis due to Exophiala jeanselmei was made. The patient was successfully treated with a combination of itraconazole and surgical excision.

Key words: phaeohyphomycosis, Exophiala jeanselmei, itraconazole