中国麻风皮肤病杂志 ›› 2026, Vol. 42 ›› Issue (1): 59-60.doi: 10.12144/zgmfskin202601059

• 病例报告 • 上一篇    下一篇

铁钉刺伤致皮肤普通变形杆菌感染一例

马山山1,潘晴2，3,卢宪梅2,3,刘红2,3,张福仁2,3   

  1. 1 山东第一医科大学附属中心医院，山东济南，250000；2 山东第一医科大学附属皮肤病医院，山东济南，250022；3 山东省皮肤病性病防治研究所，山东济南，250022
  • 出版日期:2026-01-15 发布日期:2026-01-16

Cutaneous Proteus vulgaris infection after an iron nail puncture injury: a case report

MA Shanshan1, PAN Qing2,3, LU Xianmei2,3, LIU Hong2,3, ZHANG Furen2,3   

  1. 1 Central Hospital Affiliated To Shandong First Medical University, Jinan 250000, China; 2 Dermatology Hospital of Shandong First Medical University, Jinan 250022, China; 3 Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan 250022, China
  • Online:2026-01-15 Published:2026-01-16

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摘要： 患者，男，69岁。左手背部红斑、肿胀、溃疡病史6个月。发病前除有铁钉刺伤史外，无昆虫或动物咬伤史。组织病理学检查结果为感染性肉芽肿。PAS染色未见菌丝和孢子。抗酸染色阴性。细菌培养阳性。经PCR扩增和16S rRNA测序确定为普通变形杆菌。综上诊断为普通变形杆菌皮肤感染。经盐酸米诺环素单药口服治疗3个月后皮损完全消退，随访2年无复发。

关键词: 普通变形杆菌, 感染性肉芽肿, 16S rRNA基因测序, 米诺环素

Abstract: A 69-year-old male presented with a 6-month history of erythema, swelling, and ulceration on the dorsum of his left hand. Prior to the onset, he had a history of iron nail puncture without insect or animal bite. Histopathological examination revealed infectious granuloma. No hyphae or spores were detected on PAS staining, and acid-fast staining was negative. Bacterial culture was positive. PCR amplification and 16S rRNA sequencing confirmed the pathogen as Proteus vulgaris. Based on the above findings, the diagnosis of Proteus vulgaris skin infection was made. The skin lesions completely resolved after 3 months of oral monotherapy with minocycline hydrochloride, and no recurrence was observed during a 2-year follow-up.

Key words: Proteus vulgaris, infectious granuloma, 16S rRNA gene sequencing, minocycline