中国麻风皮肤病杂志 ›› 2026, Vol. 42 ›› Issue (11): 821-825.doi: 10.12144/zgmfskin202611821

• 综述 • 上一篇    下一篇

妊娠期及哺乳期银屑病治疗选择与安全性研究进展

刘崇远1,2,李慧杰1,2,杨青1,2   

  1. 1山东第一医科大学附属皮肤病医院，山东济南，250022；2山东省皮肤病性病防治研究所，山东济南，250022
  • 出版日期:2026-11-15 发布日期:2026-10-29

Advances in the treatment and safety of psoriasis during pregnancy and lactation

LIU Chongyuan1,2, LI Huijie1,2, YANG Qing1,2   

  1. 1 Dermatology Hospital of Shandong First Medical University, Jinan 250022, China; 2 Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan 250022, China
  • Online:2026-11-15 Published:2026-10-29

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摘要： 女性银屑病患者中约75%处于育龄期，备孕、妊娠期与哺乳期属于特殊生理阶段，该类人群的银屑病管理需要兼顾病情控制与母婴安全，制定个体化治疗策略。但目前针对该人群的高质量临床研究证据较为有限，给临床治疗决策带来诸多挑战。现有研究提示，局部治疗与光疗仍是该阶段银屑病的首选方案；在系统治疗药物中，部分生物制剂相较于传统系统用药展现出更好的疗效与安全获益。本文检索近5年国内外相关文献，从局部治疗、光疗、传统系统药物、生物制剂及小分子靶向药物等方面，综述各类干预手段在妊娠期及哺乳期应用的疗效与安全性，以期为临床开展育龄人群银屑病的规范化安全治疗提供参考依据。

关键词: 银屑病, 妊娠, 哺乳, 生物制剂, 小分子药物

Abstract: Approximately 75% of female patients with psoriasis are of child-bearing age. Pre-pregnancy, pregnancy and lactation are special physiological periods. Psoriasis management for this population should balance disease control with maternal-infant safety and formulate individualized therapeutic strategies. However, high-quality clinical evidence targeting this group remains limited, posing considerable challenges for clinical decision-making. Existing studies suggest that topical therapy and phototherapy are still the first-line options for psoriasis in this period. Among systemic therapeutic agents, some biologics demonstrate better efficacy and safety benefits compared with conventional systemic drugs. This paper reviews relevant domestic and foreign literature published in the past five years, and summarizes the efficacy and safety of various interventions including topical therapy, phototherapy, conventional systemic agents, biologics and small-molecule targeted agents when used during pregnancy and lactation, so as to provide reference for the standardized and safe clinical treatment of psoriasis in women of child-bearing age.

Key words: psoriasis, pregnancy, lactation, biologics, mall-molecule targeted agents