中国麻风皮肤病杂志 ›› 2016, Vol. 32 ›› Issue (10): 634-637.

• 综述 • 上一篇    下一篇

IgG4相关的硬化性疾病

孙希印， 燕丽 ，刘萍， 李新功   

  1. 东营市人民医院病理科,东营，257091
  • 出版日期:2016-10-15 发布日期:2018-12-19
  • 通讯作者: 燕丽，E-mail: 879706367@qq.com

IgG4-related sclerosing diseases

SUN Xiyin, YAN Li, LIU Ping, Li Xingong   

  1. Department of Pathology, Dongying People’s Hospital, Dongying 257091, China
  • Online:2016-10-15 Published:2018-12-19
  • Contact: YAN Li，E-mail：879706367@qq.com

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摘要： IgG4相关硬化性疾病是近年被认识的一种疾病，被认为与自身细胞、体液免疫反应异常有关。患者血清IgG4水平升高，病变器官纤维化，并有显著IgG4阳性浆细胞浸润。病变可以累及许多器官，部分病例伴有皮肤的病变。皮肤病变以头颈部多见，可为红斑、斑片或皮下结节，有痒感。IgG4相关皮肤疾病糖皮质激素治疗有效。

关键词: 免疫球蛋白G, 自身免疫性疾病, 硬化性疾病, 皮肤

Abstract: IgG4-related sclerosing diseases are newly recognized, which are considered to be related to autoimmunity, including cellular and humoral immune abnormity. IgG4 levels in serum are higher than normal. Histopathological findings include fibrosis with significant inflammatory cells, mainly IgG4(+) plasma cells. Lesions can involve many internal organs. Skin lesions are mostly found in head and neck, presenting with erythema, patches or subcutaneous nodules accompanying itching. Glucocorticoid is effective in the treatment of IgG4-related skin diseases.

Key words: IgG, autoimmune disease, sclerosing disease, skin