中国麻风皮肤病杂志 ›› 2016, Vol. 32 ›› Issue (5): 275-277.

• 论著 • 上一篇    下一篇

慢性自发性荨麻疹血小板参数及P选择素的检测

马一平 李诚让 吴建兵 崔盘根 林 麟   

  1. 中国医学科学院皮肤病研究所，南京，210042
  • 出版日期:2016-05-15 发布日期:2018-12-24

Detection of the levels of platelet parameters and soluble P-selectin in the patients with chronic spontaneous urticaria

MA Yi-ping，LI Cheng-rang，WU Jian-bing，CUI Pangen, LIN Lin.   

  1. Institute of Dermatology，Chinese Academy of Medical Sciences，Nanjing 210042，China
  • Online:2016-05-15 Published:2018-12-24

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摘要： 目的： 检测慢性荨麻疹（CSU）患者血小板参数及P选择素的表达水平,并分析与疾病严重程度的相关性。方法：对120例CSU患者和40例健康对照者进行血小板相关参数和可溶性P选择素检测，并分析与自身免疫血清实验（ASST）结果、CSU疾病严重度评分（USS）的相关性。 结果： CSU组平均血小板体积（MPV）、血小板分布宽度(PDW) 和可溶性P选择素水平分别为11.23±1.36fl、13.41±2.26fl和74.16±20.32 ng/mL，明显高于正常对照组的9.38±1.24fl，11.17±2.51fl和32.14±8.37ng/mL。CSU组血小板计数为(176.16±41.05)×109/L，明显低于健康对照组的(227.35±42.33)×109/L。所有患者中USS评分与P选择素呈正相关，ASST阳性患者中USS与MPV呈正相关。结论： CSU组MPV、PDW和可溶性P选择素值升高，且与疾病严重程度相关，提示CSU患者中存在血小板活化。

关键词: 荨麻疹, 平均血小板体积, P选择素

Abstract: Objective: To detect the levels of platelet parameters and soluble P-selectin in the patients with chronic spontaneous urticaria (CSU). Methods: The levels of platelet parameters, and soluble P-selectin in 120 patients and 40 healthy controls were detected and the relationship between these parameters and autoimmune serum test (ASST) and urticaria severity score (USS) was analyzed. Results: The levels of mean platelet volume (MPV)，platelet distribution width (PDW) and soluble P-selectin were 11.23±1.36fl, 13.41±2.26fl and 74.16±20.32 ng/mL in the patients，which were significantly higher than those in controls group (9.38±1.24fl, 11.17±2.51fl and 32.14±8.37 ng/mL, respectively). The level of platelet count in CSU group was (176.16±41.05×109/L), which was significantly lower than that in controls (227.35±42.33 ×109/L). There was a significant positive correlation between USS and P-selectin levels in the patients and the correlation between USS and MPV in the patients with positive ASST was also significantly positive. Conclusion: The levels of MPV, PDW and soluble P-selectin were increased in the patients with CSU and were correlated to the disease severity. The platelets are activated in the patients with CSU.

Key words: urticaria, mean platelet volume, P-selectin