中国麻风皮肤病杂志 ›› 2016, Vol. 32 ›› Issue (8): 471-473.

• 短篇论著 • 上一篇    下一篇

沙利度胺治疗关节病型银屑病疗效评价及对血浆VEGF水平的影响

郝江华，杜小平   

  1. 甘肃省人民医院皮肤科，兰州市，730000
  • 出版日期:2016-08-15 发布日期:2018-12-29
  • 基金资助:
    甘肃省卫生行业科研计划管理项目（编号GWGL2014-14）

Efficacy of thalidomide in the treatment of psoriasis arthropathica and influence on VEGF

HAO Jianghua, DU Xiaoping.   

  1. Department of Dermatology, Gansu Provincial Hospital, Lanzhou 730000, China
  • Online:2016-08-15 Published:2018-12-29

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摘要： 目的：评价沙利度胺治疗关节病型银屑病的临床疗效以及对患者外周血中VEGF水平的影响。方法：30例关节病型银屑病患者口服沙利度胺治疗，150mg，每日1 次，疗程 12周；采用PASI评分标准及关节症状评分评价疗效。采用酶联免疫吸附试验（ELISA）测定患者治疗前后血清VEGF水平。结果：患者治疗后皮损和关节炎均较治疗前得到明显改善；血清中VEGF水平治疗后为(578.38±169.05) pg/L较治疗前（1045.56±289.28pg/L）明显下降。结论：沙利度胺治疗关节病型银屑病安全有效，其作用机制可能与抑制患者血浆VEGF有关。

关键词: 关节病型银屑病, 沙利度胺, 血管内皮生长因子

Abstract: Objective: To assess the efficacy of thalidomide in the treatment of the patients with psoriasis arthropathica and to determine the influence on the level of serum VEGF. Methods: Thirty patients with psoriasis arthropathica were treated with oral thalidomide, 150mg, once daily for 12 weeks. The efficacy of treatment was assessed by PASI scores and arthritis scoring method．The level of VEGF in the patients were detected by ELISA before and after treatment．Results: The skin lesion and arthritis were significantly improved after treatment. The serum level of VEGF after treatment was (578.38±169.05) pg/L, which was significantly lower than that before the treatment (1045.56±289.28pg/L). Conclusion: Thalidomide is effective in the treatment of psoriasis arthropathica and the mechanism may be through inhibiting the expression of VEGF.

Key words: psoriasis, thalidomide, VEGF