中国麻风皮肤病杂志 ›› 2023, Vol. 39 ›› Issue (10): 770-773.doi: 10.12144/zgmfskin202310770

• 综述 • 上一篇    下一篇

TRPV1在特应性皮炎发病机制和治疗中的研究进展

燕红霞1,花日2,贾秀娟3,王百灵1,高志清1,张小峰4,吴凤兰1,木其日1   

  1. 1内蒙古自治区国际蒙医医院皮肤科，呼和浩特，010020；2包头市蒙医中医医院皮肤科，包头，014040；3内蒙古自治区人民医院，呼和浩特，010010；4内蒙古自治区中蒙医药研究院，呼和浩特，010060
  • 出版日期:2023-10-15 发布日期:2023-10-12

Update of TRPV1 in the pathogenesis and treatment of atopic dermatitis

YAN Hongxia1, HUA Ri2, JIA Xiujuan3, WANG Bailing1, GAO Zhiqing1, ZHANG Xiaofeng4, WU Fenglan1, MU Qiri1   

  1. 1 Department of Dermatology, International Mongolian Hospital of Inner Mongolia, Hohhot 010020, China; 2 Department of Dermatology, Baotou Mongolian Medicine and Traditional Chinese Medicine Hospital, Baotou 014040, China; 3 Inner Mongolia People's Hospital, Hohhot 010010, China; 4 Traditional Chinese Medicine and Mongolian Medicine Research Center of Inner Mongolia, Hohhot 010060, China
  • Online:2023-10-15 Published:2023-10-12

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摘要： 特应性皮炎是一种常见的慢性复发性、瘙痒性、炎症性皮肤疾病，其发病率高且发病机制复杂。TRPV1为作为瞬时受体电位家族重要的一员参与了多种皮肤疾病的病理生理学及发病过程，近期研究证据亦发现TRPV1与特应性皮炎的发病机制密切的相关性，目前以TRPV1为主要靶标治疗特应性皮炎的药物取得了良好的疗效与安全性。本文就TRPV1在特应性皮炎发病机制和治疗中的研究进展进行综述。

关键词: 特应性皮炎, 瞬时受体电位家族, TRPV1, 发病机制, 治疗

Abstract: Atopic dermatitis is a common chronic recurrent, itchy and inflammatory skin disease with high incidence rate and complex pathogenesis. TRPV1, as an important member of the transient receptor potential family, participates in the pathophysiology and pathogenesis of various skin diseases. Recent research evidence has also found a strong correlation between TRPV1 and the pathogenesis of atopic dermatitis. Currently, some drugs targeting TRPV1 have achieved good efficacy and safety in treating atopic dermatitis. The update of TRPV1 in the pathogenesis and treatment of atopic dermatitis is reviewed in this paper.

Key words: atopic dermatitis, transient receptor potential family, TRPV1, pathogenesis, treatment