中国麻风皮肤病杂志 ›› 2024, Vol. 40 ›› Issue (12): 878-880.doi: 10.12144/zgmfskin202412878

• 病例报告 • 上一篇    下一篇

HIV阴性恶性梅毒二例

李万里1,2,3,赵伟1,2,温晶1,2,刘永霞1,2,侯建玲1,2,田洪青1,2   

  1. 1山东第一医科大学附属皮肤病医院，山东济南，250022；2山东省皮肤病性病防治研究所，山东济南，250022；3山东第一医科大学临床与基础医学院，山东济南，250000
  • 出版日期:2024-12-15 发布日期:2024-11-01

HIV-negative malignant syphilis: two cases report

LI Wanli1,2,3, ZHAO Wei1,2, WEN Jing1,2, LIU Yongxia1,2, HOU Jianling1,2, TIAN Hongqing1,2   

  1. 1 Hospital for Skin Diseases, Shandong First Medical University, Jinan 250022, China; 2 Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan 250022, China; 3 School of Clinical and Basic Medical Science, Shandong First Medical University, Jinan 250000, China
  • Online:2024-12-15 Published:2024-11-01

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摘要： 恶性梅毒（MS）又称溃疡结节性梅毒，是二期梅毒的一种罕见症状。本文报道2例HIV阴性的恶性梅毒，2例患者头面部均出现红斑、结节、脓疱、结痂，苄星青霉素治疗后发生吉海氏反应，后皮疹完全消退。大多MS患者伴有HIV阳性，HIV阴性伴恶性梅毒较少见。本文对恶性梅毒的诊断、鉴别诊断以及治疗进行文献复习。

关键词: 恶性梅毒, 二期梅毒, 溃疡结节性梅毒

Abstract: Malignant syphilis (MS), also known as ulceronodular syphilis, is a rare manifestation of secondary syphilis. This paper reports two cases of HIV-negative malignant syphilis. Both patients presented with erythema, nodules, pustules, and crusting on the head and face, and developed Jarisch-Herxheimer reactions following treatment with benzathine penicillin, after which their rashes completely resolved. While most MS patients are HIV-positive, cases of HIV-negative malignant syphilis are relatively rare. This paper provides a literature review on the diagnosis, differential diagnosis, and treatment of malignant syphilis.

Key words: malignant syphilis, secondary syphilis, ulceronodular syphilis