中国麻风皮肤病杂志 ›› 2024, Vol. 40 ›› Issue (5): 342-344.doi: 10.12144/zgmfskin202405342

• 病例报告 • 上一篇    下一篇

新生儿朗格汉斯细胞组织细胞增生症一例

杨玲1,张宇强1,席世兵1,孙毓徽1,胡平1,李涛1,水华2   

  1. 1湖北医药学院附属太和医院，湖北十堰，442000；2武汉大学中南医院肾病内科，湖北武汉，430060
  • 出版日期:2024-05-15 发布日期:2024-04-19

Neonatal Langerhans cell histiocytosis: a case report

YANG Ling1, ZHANG Yuqiang1, XI Shibing1, SUN Yuhui1, HU Ping1, LI Tao1, SHUI Hua2   

  1. 1 Taihe Hospital Affiliated to Hubei Medical College, Shiyan 442000, China; 2 Department of Nephrology, Central South Hospital, Wuhan University, Wuhan 430060, China
  • Online:2024-05-15 Published:2024-04-19

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摘要： 患儿，女，27天，生后半月出现皮疹、发热、肝脾肿大、贫血、血小板减少、消化道出血等表现，经皮肤活检病理及免疫组化最终诊断为新生儿多系统朗格汉斯细胞组织细胞增生症。给予泼尼松、长春新碱化疗，成功挽救患儿。随诊至患儿11月龄，体重增加良好、食纳可，多次查血常规及肝肾功能等指标无异常，病情稳定。

关键词: 新生儿朗格汉斯细胞组织细胞增生症, 皮疹, 发热, 血小板减少, 消化道出血

Abstract: A 27-day-old infant presented with rash, fever, hepatosplenomegaly, anemia, thrombocytopenia, and gastrointestinal bleeding in the postnatal half a month. According the features of skin biopsy and immunohistochemistry, the final diagnosis was neonatal multi-system Langerhans cell histiocytosis. The patient was successfully treated with chemotherapy of prednisone and vincristine actively. Follow up until 11 months old, good weight gain and appetite, multiple blood tests, liver and kidney function indicators are normal, and the condition is stable.

Key words: neonatal multi-system Langerhans cell histiocytosis, rash, fever, thrombocytopenia, gastrointestinal bleeding