中国麻风皮肤病杂志 ›› 2026, Vol. 42 ›› Issue (1): 61-66.doi: 10.12144/zgmfskin202601061

• 综述 • 上一篇    下一篇

人乳头瘤病毒感染模型构建研究进展

宋佳琪1,宋寅敬2,汤怡3   

  1. 1杭州医学院公共卫生学院，浙江杭州，310013； 2浙江大学医学院附属邵逸夫医院，浙江杭州，310016； 3浙江省人民医院，杭州医学院附属人民医院，浙江杭州，310014
  • 出版日期:2026-01-15 发布日期:2026-01-16

Research progress in the construction of human papillomavirus infection models

SONG Jiaqi1, SONG Yinjing2, TANG Yi3   

  1. 1 School of Public Health, Hangzhou Medical College, Hangzhou 310013, China; 2 Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China; 3 Department of Dermatology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou 310014, China
  • Online:2026-01-15 Published:2026-01-16

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摘要： 人乳头瘤病毒（human papillomavirus，HPV）感染是最常见的性传播疾病之一，其致癌作用已经得到了广泛的研究，针对治疗HPV感染所建立的模型主要有二维细胞模型、三维类器官模型、兔模型、鼠模型等。由于HPV具有高度的宿主特异性，传统模型难以模拟病毒-宿主动态互作，型别特异性建模体系也尚未建立。本文对HPV感染现有建模体系进行系统综述。

关键词: 人乳头瘤病毒, 细胞模型, 类器官, 动物模型

Abstract: Human papillomavirus (HPV) infection is one of the most common sexually transmitted diseases, and its carcinogenic effect has been extensively studied. The models established for the treatment of HPV infection mainly include two-dimensional cell models, three-dimensional organoid models, rabbit models, mouse models, etc. Due to the high host specificity of HPV, traditional models are difficult to simulate the dynamic virus-host interaction, and a genotype-specific modeling system has not yet been established. This review provides a systematic review of the existing modeling systems for HPV infection.

Key words: HPV, cellular models, organoid, animal model