中国麻风皮肤病杂志 ›› 2026, Vol. 42 ›› Issue (5): 378-381.doi: 10.12144/zgmfskin202605378

• 综述 • 上一篇    下一篇

硬化萎缩性苔藓治疗进展

邵泓源1,2,田洪青1,2   

  1. 1山东第一医科大学附属皮肤病医院,山东济南，250022;2山东省皮肤病性病防治研究所,山东济南，250022
  • 出版日期:2026-05-15 发布日期:2026-05-12

Treatment advances in lichen sclerosus

SHAO Hongyuan1,2, TIAN Hongqing1,2   

  1. 1 Dermatology Hospital of Shandong First Medical University, Jinan 250022, China; 2 Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan 250022, China
  • Online:2026-05-15 Published:2026-05-12

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摘要： 硬化萎缩性苔藓是一种病因未明的慢性炎症性皮肤病，好发于外生殖器部位，常导致瘙痒、疼痛、排尿困难及性交痛等症状，严重影响患者生活质量，并与鳞状细胞癌风险增加相关。本病传统治疗，如局部外用糖皮质激素治疗、钙调神经磷酸酶抑制剂等，虽可缓解症状，但复发率高，长期应用不良反应大。近期研究进展包括光动力治疗、富血小板血浆局部注射、生物制剂及小分子药物治疗等，可提高疗效减少不良反应。本文就硬化萎缩性苔藓的治疗进展进行综述。

关键词: 硬化萎缩性苔藓, 治疗

Abstract: Lichen sclerosus is a chronic inflammatory skin disease of unknown etiology, predominantly affecting the genital area. It often leads to symptoms such as pruritus, pain, dysuria, and dyspareunia, significantly impairing patients' quality of life and is associated with an increased risk of squamous cell carcinoma. Although conventional treatments can alleviate symptoms, their long-term efficacy is often unsatisfactory, and they face challenges such as high recurrence rates and potential disease progression. New therapies, including photodynamic therapy, local injection of platelet-rich plasma, biologics and small-molecule drug therapy, etc. have shown certain advancements. This paper provides a review of the progress in the treatment of lichen sclerosus.

Key words: lichen sclerosus, treatment