关键词: 天疱疮, 糖皮质激素, 免疫抑制剂, 静脉注射免疫球蛋白, 利妥昔单抗, 免疫吸附, 血浆置换

Abstract: Although glucocorticoid is the mainstay in the treatment of pemphigus, some adjuvant therapies, such as immunosuppressants, intravenous immunoglobulin, rituximab, plasma exchange, and immunosorbent therapy have been gradually used in the treatment of pemphigus, especially for refractory cases. These treatments not only help to improve the prognosis of the disease and reduce the risk of relapse, but also contribute to sparing of glucocorticoids. Furthermore, some emerging immune therapies, such as chimeric antigen receptor, T lymphocyte immunotherapy and B-cell activating factor, etc. may provide with alternate treatments in the future. The above therapies are reviewed in this paper.

Key words: pemphigus, glucocorticoids, immunosuppressants, intravenous immunoglobulin, rituximab, immunosorbent, plasmapheresis