中国麻风皮肤病杂志 ›› 2021, Vol. 37 ›› Issue (11): 744-747.doi: 10.12144/zgmfskin202111744

• 综述 • 上一篇    下一篇

细胞间黏附分子CD146在皮肤病中的研究进展

王喆,刘红,张福仁    

  1. 山东第一医科大学附属皮肤病医院(山东省皮肤病医院，山东省皮肤病性病防治研究所)，济南，250022
  • 出版日期:2021-11-15 发布日期:2021-09-15
  • 通讯作者: 张福仁，E-mail: zhangfuren@hotmail.com

Update of intercellular adhesion molecule CD146 in skin diseases

WANG Zhe, LIU Hong, ZHANG Furen   

  1. Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Veneorology, Shandong First Medical University, Jinan 250022, China
  • Online:2021-11-15 Published:2021-09-15
  • Contact: ZHANG Furen, E-mail: zhangfuren@hotmail.com

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摘要： CD146是一种黏附分子，主要表达于血管内皮细胞。最近研究表明，CD146在多种皮肤病中发挥重要作用。CD146有三种形式，包括两种膜型异构体和一种可溶型分子。CD146分子通过与不同的配体结合可以介导不同的生物学功能。本文综述了CD146分子的结构、定位、调节和功能及在皮肤病中的研究进展。

关键词: CD146, 皮肤病

Abstract: CD146 is an adhesion molecule, which is mainly expressed by vascular endothelial cells. Recent studies have shown that CD146 plays an important role in several skin diseases. Three forms of CD146 have been described, including two transmembrane isoforms and a soluble protein. CD146 can mediate pleiotropic biological functions through interactions with different ligands. The update of the structure, location, regulation and function of CD146 molecules and research progress in skin diseases is reviewed in this article.

Key words: CD146, skin diseases