中国麻风皮肤病杂志 ›› 2023, Vol. 39 ›› Issue (8): 583-586.doi: 10.12144/zgmfskin202308583

• 临床研究 • 上一篇    下一篇

氨苯砜治疗持久性隆起性红斑合并睑黄瘤一例

李艳艳,周桂芝,刘红,张福仁   

  1. 山东第一医科大学附属皮肤病医院（山东省皮肤病医院），山东省皮肤病性病防治研究所，山东济南，250022
  • 出版日期:2023-08-15 发布日期:2023-07-19

Successful treatment with dapsone for erythema elevatum diutinum complicated with xanthelasma

LI Yanyan, ZHOU Guizhi, LIU Hong, ZHANG Furen   

  1. Shandong Provincial Hospital for Skin Diseases ＆ Shandong Provincial Institute of Dermatology and Veneorology, Shandong First Medical University ＆ Shandong Academy of Medical Sciences, Jinan 250022, China
  • Online:2023-08-15 Published:2023-07-19

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摘要： 持久性隆起性红斑合并黄瘤病的病例尚未见报道,本文报道氨苯砜成功治疗持久性隆起性红斑与黄瘤病一例。46岁女性患者全身多发淡红色丘疹、斑块2年，双上眼睑可见米粒大的金黄色丘疹1年。右上臂红色丘疹组织病理示表皮变薄，真皮浅中层血管周及胶原间嗜中性粒细胞、少许嗜酸性粒细胞、淋巴细胞浸润，未见明显血管壁纤维蛋白样变；上眼睑黄色斑块的反射式共聚焦显微镜示真皮浅中层见多量泡沫细胞，病变区表皮基本正常。氨苯砜治疗7周后，患者多发红斑完全消退。10个月后，患者的睑黄瘤斑块消退。

关键词: 持久性隆起性红斑, 睑黄瘤, 氨苯砜

Abstract: The case of erythema elevatum diutinum (EED) complicated with xanthomatosis has not been reported . This paper reports a case of EED complicated with xanthelasma successfully treated with dapsonea. A 46-year-old famale presented with pruritic erythema all over the body for 2 years, and a yellow plaque in the size of a grain of rice deep on the double upper eyelid for 1 year. Skin biopsy of the erythema suggested thinner epidermis, and neutrophils, a few eosinophils and infiltration of lymphocytes around the blood vessels, no bvious fibrinoid changes were observed in the vascular wall. The finding of reflectance confocal microscopy of yellow plaque indicated that many of foam cells in the middle layer of the dermis, the epidermis was basically normal. The multiple erythema and yellow plaque completely subsided after 7 weeks and 10 months of treatment with dapsone respectively.

Key words: erythema elevatum diutinum, xanthelasma, dapsone