中国麻风皮肤病杂志 ›› 2024, Vol. 40 ›› Issue (5): 371-376.doi: 10.12144/zgmfskin202405371

• 综述 • 上一篇    下一篇

基于疾病修饰的大疱性类天疱疮治疗进展

吴倩,姜福琼,游淑琼,王媛,吴永卓   

  1. 昆明医科大学第二附属医院皮肤科，云南昆明，650101
  • 出版日期:2024-05-15 发布日期:2024-04-22

Update of the treatment of bullous pemphigoid based on disease-modifying

WU Qian, JIANG Fuqiong, YOU Shuqiong, WANG Yuan, WU Yongzhuo   

  1. Dermatology Department, the Second Affiliated Hospital of Kunming Medical University, Kunming 650101, China
  • Online:2024-05-15 Published:2024-04-22

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摘要： 大疱性类天疱疮（bullous pemphigoid，BP）主要治疗方式为使用糖皮质激素和免疫抑制剂，而长期使用这些药物可能出现严重的不良反应，且病情复发率较高。近年来，随着BP疾病修饰的相关研究不断深入，BP的靶向治疗受到很大关注，越来越多的新型药物应用于临床。本文基于BP疾病修饰的相关研究，对当前BP新靶点药物的研究进展进行综述。

关键词: 大疱性类天疱疮, 靶向治疗, 疾病修饰, 治疗机制, 小分子抑制剂

Abstract: Glucocorticoids and immunosuppressants are the main treatment modalities for bullous pemphigoid (BP). However, long-term use of these drugs can cause serious side effects, and the recurrence rate remains high. With the research on disease-modifying of BP, the targeted therapy of BP has received great attention, the more and more new drugs have been applied in clinic. Based on the relevant research on disease modification of BP, this paper reviews the current research progress of new target drugs of BP. 

Key words: bullous pemphigoid, target therapy, disease-modifying, therapeutic mechanism, small molecule inhibitors