中国麻风皮肤病杂志 ›› 2023, Vol. 39 ›› Issue (12): 936-940.doi: 10.12144/zgmfskin202312936

• 综述 • 上一篇    

白癜风系统及外用靶向免疫治疗进展

单娇,孙勇虎   

  1. 山东第一医科大学附属皮肤病医院（山东省皮肤病医院），山东省皮肤病性病防治研究所，山东济南，250022
  • 出版日期:2023-12-15 发布日期:2023-11-22

Update of systemic and topical targeted immunotherapy for vitiligo

SHAN Jiao, SUN Yonghu   

  1. Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Veneorology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250022, China
  • Online:2023-12-15 Published:2023-11-22

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摘要： 白癜风是色素细胞损伤致皮肤黏膜以白斑为主要表现的自身免疫性疾病，易诊断难治疗。其治疗方法多为超适应症用药，缺乏特异性治疗药物。近年来，有多项研究结果表明系统及外用靶向免疫药物，包括生物制剂和小分子药物等对白癜风治疗有效，为白癜风的治疗带来了新的希望。本文对近年来白癜风系统及外用靶向免疫治疗方面的临床研究进行综述，为白癜风的临床治疗提供参考。

关键词: 白癜风, 靶向免疫治疗, 生物制剂, 小分子抑制剂

Abstract: Vitiligo is an autoimmune disease present with pigment cell damage related white patch for both skin and mucosa, which is easy to diagnose and difficult to treat. Current treatment options are mostly off-label and lack specific therapeutic drugs. In recent years, several studies have shown that systemic and topical targeted immunotherapy, including biological agents and small-molecule inhibitors, are effective in the treatment of vitiligo, shedding new light on the treatment of vitiligo. We review the clinical studies of systemic and topical targeted immunotherapy in recent years to add knowledge for the clinical treatment of vitiligo.

Key words: vitiligo, targeted immunotherapy, biological agent, small-molecule inhibitor