抑郁焦虑情绪对复发性尖锐湿疣患者外周血调节性T细胞水平的影响

中国麻风皮肤病杂志 ›› 2016, Vol. 32 ›› Issue (9): 544-546.

抑郁焦虑情绪对复发性尖锐湿疣患者外周血调节性T细胞水平的影响

程芳¹，赵学良²，陶书杰²，王秀佳¹，王辉²，赵红英¹，房黎亚¹，于新¹，王金超¹，李惠¹

1.潍坊医学院，山东潍坊261042； 2.潍坊市人民医院皮肤科，山东潍坊261000

出版日期:2016-09-15 发布日期:2018-12-14
通讯作者: 陶书杰，E-mail:zhxl5801@163.com

Impact of depression and anxiety on the level of peripheral blood Treg cells in the patients with recurrent condyloma acuminatum

CHENG Fang¹, ZHAO Xueliang², TAO Shujie², WANG Xiujia¹, WANG Hui ², ZHAO Hongying¹, FANG Liya¹, YU Xin¹, WANG Jinchao¹, LI Hui¹

1.Wei Fang Medical University, Weifang 261042, China；2.Wei Fang People,s Hospital, Weifang 261000, China

Online:2016-09-15 Published:2018-12-14
Contact: TAO Shujie, E-mail:zhxl5801@163.com

摘要/Abstract

摘要： 目的: 确定抑郁焦虑情绪对CA复发和细胞免疫的影响。方法: 采用抑郁自评量表（SDS）和焦虑自评量表(SAS)对100例初诊CA进行问卷调查，评估其情绪状态。SDS>50和/或SAS>50为抑郁焦虑者，其余患者为非抑郁焦虑者。选择健康体检32人为对照。流式细胞技术测定外周血Treg细胞水平。随后观察两组CA治疗后的复发率。结果: CA组外周血Treg细胞水平为(8.03±2.14)%，显著高于正常对照组（5.28±1.21）% （P<0.05）；抑郁焦虑组外周血Treg细胞水平为（8.64±2.12）%,显著高于无抑郁焦虑组（7.55±2.05）% （P<0.05）。治疗后抑郁焦虑组第1、2、3、6个月的复发率均高于无抑郁焦虑组。结论:抑郁和/或焦虑情绪可加剧CA患者细胞免疫功能的抑制，导致CA更易复发。

关键词: 抑郁, 焦虑, 尖锐湿疣, CD4+CD25+Foxp3+调节性T细胞

Abstract: Objective: To determine the impact of depression and anxiety on the immunological status and recurrence in the patients with condyloma acuminatum (CA). Methods: The emotional state of 100 CA patients was evaluated with Self-rating Depression Scale (SDS) and Self-rating Anxiety Scale (SAS). If SDS>50 and/or SAS>50, the patient was judged as having depression and anxiety, otherwise, as having no depression and anxiety. The level of peripheral blood regulatory T cells were assayed by flow cytometry. Results: The level of peripheral blood regulatory T cells was significantly higher in CA patients (8.64±2.12)% than in the normal control group （5.28±1.21）%. The level of peripheral blood regulatory T cells among the patients with depression and anxiety (8.64±2.12)% was significantly higher than that among the patients without depression and anxiety (7.55±2.05)%. The recurrence rate of CA after treatment was higher in the patients with depression and anxiety than in the patients without depression and anxiety at month 1, 2, 3 and 6. Conclusion: Depression and anxiety may increase inhibition of cellular immune function in CA patients, resulting in higher likelihood for CA relapse.

Key words: depression, anxiety, condyloma acuminatum, CD4+CD25+Foxp3+ regulatory T cells

程芳, 赵学良, 陶书杰, 王秀佳, 王辉, 赵红英, 房黎亚, 于新, 王金超, 李惠. 抑郁焦虑情绪对复发性尖锐湿疣患者外周血调节性T细胞水平的影响[J]. 中国麻风皮肤病杂志, 2016, 32(9): 544-546.

CHENG Fang, ZHAO Xueliang, TAO Shujie, WANG Xiujia, WANG Hui , ZHAO Hongying, FANG Liya, YU Xin, WANG Jinchao, LI Hui. Impact of depression and anxiety on the level of peripheral blood Treg cells in the patients with recurrent condyloma acuminatum[J]. China Journal of Leprosy and Skin Diseases, 2016, 32(9): 544-546.

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