中国麻风皮肤病杂志 ›› 2019, Vol. 35 ›› Issue (1): 25-27.doi: 10.12144/zgmfskin201901025

• 论著 • 上一篇    下一篇

泌乳素及其受体在尖锐湿疣的表达

江中洪  江玉娥  曾茂森   

  1. 嘉应学院医学院附属医院，广东梅州,514031
  • 出版日期:2019-01-15 发布日期:2019-02-26
  • 通讯作者: 江中洪，E-mail: aflas@163.com

Expression of prolactin and its receptor in the patients with condyloma acuminatum

JIANG Zhonghong, JIANG Yu'e, ZENG Maosen   

  1. Department of Dermatology, the Affiliated Hospital of Medical College of JiaYing University, Meizhou 514031, China
  • Online:2019-01-15 Published:2019-02-26
  • Contact: JIANG Zhonghong, E-mail: aflas@163.com

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摘要： 目的：检测泌乳素(PRL)及其受体(PRLR)在尖锐湿疣(CA)患者中的表达。方法：采用化学发光法检测40例CA患者(男20例，女20例)和40名对照(男20名，女20名)血PRL。免疫组化检测40例皮损及20名健康包皮手术者包皮的PRLR表达水平。结果：男性CA患者和男性对照PRL水平分别为(9.24±4.68)ng/mL和(8.42±3.83)ng/mL，差异无统计学意义；女性CA患者和女性对照血PRL分别为(14.62±6.23)ng/mL和(12.42±5.46)ng/mL，差异无统计学意义；40例CA患者皮损和20名对照PRLR细胞阳性率分别为97.50%和80.00%，差异有统计学意义(P<0.05)。结论：PRL可能促进表皮角质形成细胞和血管内皮细胞增殖,从而导致疣体的形成。

关键词: 尖锐湿疣, 泌乳素, 泌乳素受体

Abstract: Objective: To detect the expression level of prolactin (PRL) and its receptors (PRLR) in the patients with condyloma acuminatum (CA). Methods: The level of PRL in peripheral blood of 40 patients (20 males and 20 females) with CA and 40 healthy controls (20 males and 20 females) was detected by chemiluminescence method. The expression of PRLR was detected by immunohistochemistry in the lesions of 40 patients and 20 foreskin samples. Results: The expression level of PRL in 20 male patients and 20 male controls were 9.24±4.68 ng/mL and 8.42±3.83 ng/mL, with no significant difference (P>0.05). The expression level of PRL in 20 female patients and 20 female controls were 14.62±6.23 ng/mL and 12.42±5.46 ng/mL, with no significant difference (P>0.05).  The cell positivity rates of PRLR in the lesions and foreskin samples were 97.50% and 80.00%, with a significant difference (P<0.05). Conclusion: The  over-expression of PRL may promot the proliferation of epidermal keratinocytes and vascular endothelial cell proliferation, resulting in the formation of the warts. 

Key words: condyloma acuminatum, prolactin, prolactin receptor