中国麻风皮肤病杂志 ›› 2019, Vol. 35 ›› Issue (1): 50-53.doi: 10.12144/zgmfskin201901050

• 综述 • 上一篇    下一篇

T细胞DNA甲基化在部分皮肤病中的研究进展

吴明顺  周伏圣  张学军   

  1. 安徽医科大学皮肤病研究所，安徽医科大学第一附属医院皮肤性病科，合肥,230032
  • 出版日期:2019-01-15 发布日期:2019-02-27
  • 通讯作者: 张学军，E-mail: ayzxj.@vip.sina.com

Update of DNA methylation in T Cells of some skin disorders

WU Mingshun , ZHOU Fusheng, ZHANG Xuejun   

  1. Department of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, China
  • Online:2019-01-15 Published:2019-02-27
  • Contact: ZHANG Xuejun, E-mail: ayzxj.@vip.sina.com

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摘要： DNA甲基化是一种常见的表观遗传学修饰途径，与多种皮肤病的发病机制密切相关。T细胞包括CD8+T细胞、CD4+T细胞等。T细胞参与多种皮肤病如银屑病、系统性红斑狼疮（systemic lupus erythematosus，SLE）、系统性硬皮病(systemic scleroderma,SS)、原发性干燥综合征(primary Sjogrens syndrome,pSS)等疾病的免疫应答过程，是参与疾病发生发展的重要调节性细胞。本文主要是从T细胞DNA甲基化的角度出发，对疾病的发病机制及研究进展进行综述。

关键词: T细胞, DNA甲基化, 皮肤病

Abstract: DNA methylation is a common modification pathway in epigenetics, which is closely related to the pathogenesis of various skin disorders. T cells include CD8+ T cells, CD4+ T cells and so on, which involve in immune responses and work as important regulatory cells in the development of skin diseases such as psoriasis, systemic lupus erythematosus, systemic scleroderma, and primary Sjogrens syndrome. The update on the pathogenesis and research progress of these diseases, particularely from the point view of DNA methylation in T cells, is made.

Key words: T cells, DNA methylation, skin disorders