Abstract: Objective: To understand the family history data and annalyzed the epidemiological characteristics of leprosy patients with family history were mastered by more detailed investigation. Methods: A total of 2210 leprosy survivors were included. Family history and clinical information were obtained by of leprosy survivors by reviewing the original medical records and patient registration forms, investigating skin prevention workers and township doctors, and household follow-up. One-way t-test and chi-square test were performed by SPSS 25.0. Results: 1964 leprosy survivors was actually included in the analysis. The sex ratio of male to female was 3.9∶1, the mean age of onset was 22.18±12.14 years old, the mean age of diagnosis was 25.64±11.89 years old. The mainly type was tuberculoid leprosy （1026, 52.24%）and lepromatous leprosy（725, 36.91%）. There were 399 cases (20.32%)with a family history. The proportion of female（24.44%）leprosy patients with family history was higher than that of male（19.26%）. The proportion of Multibacillary (MB)（27.77%）leprosy patients with family history was higher than Paucibacillary (PB)（18.38%） patients. Conclusion:In this study, accurate information on the family history of leprosy survivors was obtained by the verification of original medical records, investigation of skin prevention workers and follow-up of leprosy cases. About one fifth of the leprosy patients have the family history, which suggests that we should carry out the key follow-up of the related relatives of leprosy patients especially multibacillary, including extending the follow-up time and increasing the frequency of follow-up, so as to improve the early detection level of leprosy.

Key words: leprosy, data verification, family history, epidemiological analysis