Abstract: Objective: To investigate the epidemiological characteristics of leprosy in Zhejiang Province from 1995 to 2020, and to provide a reliable basis for the formulation of leprosy prevention and control plan in the 14th Five-year Plan. Methods: The data of leprosy in Zhejiang province were collected in all kinds of reports of leprosy epidemic situation in all areas of zhejiang province and LEPMIS as well as related data of the the plan for the elimination of leprosy hazards in Zhejiang Province, analyzed by descriptive epidemiological method. Results: A total of 493 leprosy cases were found in Zhejiang during 1995-2020 with an average case detection rate of 0.04 per 100 000 population and the prevalence rate of 0.19 per 100 000 population, both showed a decreasing trend. Compared with 1995-2010, the average age of new cases from 2011 to 2020 was younger than before, the household registration was mainly distributed among floating population. LL was the most common among the new cases(33.87%). The proportion of multi-bacteria increased from 72.41% to 93.68%, and the average delay period decreased from 34.1 months to 20.7 months. The ratio of early detection increased from 46.71% to 70.69%, and the proportion of newly diagnosed dermatologists increased from 80.56% to 91.95%. The completion rate of treatment was 89.7%. No daspone synthesis was found in new cases after 2015. Conclusion: The epidemic characteristics of leprosy in Zhejiang province showed a downward trend, and the prevention and control work achieved remarkable results. However, it still faces the problem of imported cases caused by population movement, which makes it difficult to detect and monitor. Therefore, it is necessary to continue to strengthen the monitoring of suspected symptoms of leprosy, improve the prevention and treatment network, stabilize the prevention and treatment team and strengthen the publicity of core knowledge of leprosy, so as to detect patients as soon as possible and diagnose and treat them in time.

Key words: Zhejiang, leprosy, epidemiology