Abstract: Objective: To investigate the epidemiological characteristics of leprosy in Guiyang from 2005 to 2020. Methods: The detailed data of new and recurrent leprosy patients in Guiyang from 2005 to 2020 were collected through the National Leprosy Prevention and Management Information System (LEPMIS). SPSS 18.0 software was used for χ2 test and multivariate logistic regression analysis on the related factors such as general information, times of visit, leprosy reaction, disability, source of infection, detection method and type of leprosy. Results: A total of 169 cases of new and recurrent leprosy were found in Guiyang from 2005 to 2020, with an average annual detection rate of 0.260/105, showing a general downward trend. Of 169 patients, 7 were relapsed cases, including 3 relapsed after MDT (42.86%) and 4 relapsed after DDS (57.14%). The mean age was 41.88±16.75 years, and 6 cases were children (14 years or younger), accounting for 3.55% of the new cases, MB∶PB=2.13∶1. The average rate of grade 2 disability was 32.54%. Skin clinic was the main detection mode, accounting for 31.36%. The main factors associated with disability were the education level of leprosy patients, different sources of infection, detection methods and types of leprosy. Conclusion: The prevalence of leprosy in Guiyang was generally declining. However, with a high level 2 disability ratio and the emergence of cases in children (14 years or younger), the leprosy epidemic situation remains severe. 

Key words: leprosy, epidemiological, characteristics analysis