Abstract: We report a case of erythema elevatum diutinum associated with multiple systemic damage. The patient was admitted to the hospital due to plaque nodules and pain in the extremities and buttocks for more than 2 years. During the course of the disease, symptoms such as eye pain, blurred vision, limb joint pain, and dull pain around the umbilical cord occurred. The diagnosis was confirmed by histopathology. Giving the rash, abdominal pain, joint pain improved after treated by glucocorticoid and hydroxychloroquine.

Key words: erythema elevatum diutinum')">">erythema elevatum diutinum, multiple systemic damage, treatment