Abstract: Pyoderma gangrenosum (PG) is a neutrophilic dermatosis characterized by recurrent, painful and necrotizing ulcers. There is neither consensus nor effective therapeutics on PG treatment at present, glucocorticoids were first-line treatment in clinical practice, immunosuppressants and other drugs can be used alone or in combination with glucocorticoids, but there's still difficulty achieving satisfactory results for some patients. Nowadays, biological agents and small molecule drugs have gradually applied to the treatment of PG and achieved certain effects. This review aims to summarize the efficacy and safety of targeted agents such as biological agents and JAK inhibitors to provide reference for clinical treatment.

Key words: pyoderma gangrenosum')">pyoderma gangrenosum, treatment, biological agents, JAK inhibitors