Abstract: Objective: November 19, 2022, an elderly inpatient with psoriasis in our hospital tested positive for COVID-19, the elder patient had high fever, hypertension, high cytokine levels, and a history of coronary heart disease, we conducted this emergency response to quickly treat the patient and control the spread of COVID-19 in our hospital. Methods: According to the National COVID-19 Control and treatment Protocol (9th edition), and the Emergency Response Plan for COVID-19 in our hospital (11th edition), information reporting, hospital blockading, COVID-19 nucleic acid test for single person, inpatient treatment, close contact screening, environmental disinfecting, case transport to designated hospital, and risk assessment were carried. The elderly patient was treated with IL-6 receptor antagonist and human immunoglobulin et al. Results: After treatment, the patient did not develop severe symptoms such as dyspnea, blood pressure and body temperature returned to normal, and there was no discomfort during 1 month follow-up. A total of 12 close contacts were determined. Among them, the patient's daughter and a nurse in our hospital tested positive for COVID-19 during quarantine observation and recovered after symptomatic treatment. After overnight response, the risk of COVID-19 spread was under control, without affecting the treatment of inpatients and outpatients. Conclusion: The treatment of combination of IL-6 receptor antagonist and human immunoglobulin successfully treated an elderly COVID-19 positive patient with psoriasis and coronary heart disease, avoiding the patient becoming severe, and providing a new idea for the treatment of elderly COVID-19 patients.

Key words: COVID-19 infection, elder inpatient, treatment