Abstract: Objective: To analyze the clinical features and treatment measures of HIV complicated with severe drug eruption. Methods: A retrospective analysis was carried out on the clinical data of inpatients with HIV complicated with severe drug eruption admitted to Chongqing Public Health Medical Center from January 2017 to December 2020. Results: A total of 40 patients were included in this study, including 23 cases of SJS, 15 cases of ED and 2 cases of TEN. The mean age was 48.7±12.8 years, and 85% (34/40) of men. Top three sensitization drugs: efevirenz, sulfanilamide and traditional Chinese medicine preparation. The most common manifestations were fever (52.5%) and pruritus (80%). 90% had mucosal involvement, 82.5% had liver involvement. 65% had cutaneous infections. The median of CD4 count was 113/μL (from 14 to 713/μL). There were significant differences of fever and cutaneous infection among the three kinds of severe drug eruption (P_s<0.05). The mean maximum dose of glucocorticoid was 78±12.6 mg/d, and the mean total dose of immunoglobulin was 111.4±22.9 g. Three patients died, the cause of death was not drug eruption, but complications of AIDS. Conclusion: HIV complicated with severe drug outbreak was more common in middle-aged men, with an average incubation period of about 10 days, and it was common in patients who used efevirenz, cotrimoxazole, traditional Chinese medicine preparations and tuberculosis drugs. Early sufficient use of glucocorticoid combined with immunoglobulin shock therapy had better efficacy.

Key words: HIV, severe drug eruption, clinical characteristics, treatment measures