Abstract: Drug induced hypersensitivity syndrome (DIHS) is a severe adverse drug reaction. Genetic susceptibility, drug-metabolizing enzymes deficiency, immune changes and virus reactivation may be involved in the etiology of DIHS. The traditional treatment includes glucocorticoids, immunosuppressant, intravenous immunoglobulin, plasmapheresis and so on. The research of DIHS has made certain progress and the application of targeted small-molecule inhibitors and biologic agents have been used successfully to treat DIHS in recent years. The pathogenesis and therapeutic advances of DIHS are reviewed in this paper.

Key words: drug induced hypersensitivity syndrome, drug reaction with eosinophilia and systemic symptoms, pathogenesis, treatments