结外NK/T细胞淋巴瘤,皮肤结节,嗜酸性粒细胞增多," /> 结外NK/T细胞淋巴瘤,皮肤结节,嗜酸性粒细胞增多,"/> extranodal NK/T cell lymphoma, skin invasion, eosinophilia,"/> <span style="font-size:12px;">Rare extranodal NK/T cell lymphoma presenting as eosinophilic syndrome: a case report</span>

China Journal of Leprosy and Skin Diseases ›› 2024, Vol. 40 ›› Issue (2): 127-130.doi: 10.12144/zgmfskin202402127

• Case Reports • Previous Articles     Next Articles

Rare extranodal NK/T cell lymphoma presenting as eosinophilic syndrome: a case report

ZHANG Beibei1, LIU Ligen2, SONG Ningjing1   

  1. 1 Department of Dermatology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China;
    2 Department of Hematology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China
  • Online:2024-02-15 Published:2024-01-31

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Abstract: A 53-year-old male presented with recurrent skin erythema and subcutaneous nodules of lower extremities for 1 year, fever for more than 1 month. Hematology findings showed a peripheral blood eosinophilic granulocyte count of 4.92×109/L (55.3%), Epstein-Barr virus DNA showed positive. Skin biopsy showed a dense infiltration of mononuclear cells surrounded blood vessels, with atypic changes and a large number of eosinophil infiltration. Immunohistochemistry: CD3(+), Ki67(80%), TIA1(+), Granzyme B(+), Perforin(+), EBER(+). Biopsy of nasal mucosa and laryngeal masses showed heterotypic cells. The diagnosis of extranodal NK/T cell lymphoma (ENKTL) was made.

Key words: extranodal NK/T cell lymphoma')">">extranodal NK/T cell lymphoma, skin invasion, eosinophilia