Abstract: Metformin, an oral antidiabetic drug, has shown potential in skin anti-aging, primarily through inhibiting oxidative stress reactions, enhancing cellular autophagy function to delay aging, and reducing the incidence and overall mortality of age-related diseases. The paper reviews the anti-aging mechanisms of metformin to provide new insights for the study and development of anti-aging drugs.

Key words: metformin')">">metformin, skin aging, oxidative stress, cellular autophagy