China Journal of Leprosy and Skin Diseases ›› 2025, Vol. 41 ›› Issue (10): 738-740.doi: 10.12144/zgmfskin202510738

• Case Reports • Previous Articles     Next Articles

A case of sclerodermatiform chronic graft-versus-host disease complicated with giant squamous cell carcinoma

LIU Maolin1, SUN Yihan2, HUANG Zhe1, KANG Xu2, MO Xiumei2,3   

  1. 1 The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, China; 2 Guangdong Hospital of Traditional Chinese Medicine, Guangzhou 510120, China; 3 Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases, Guangzhou 510030, China
  • Online:2025-10-15 Published:2025-09-28

Abstract: A 45-year-old male patient underwent bone marrow transplantation 20 years ago due to “chronic myeloid leukemia”. After the operation, he took methylprednisolone tablets regularly. Three years later, he developed scleroderma-like graft-versus-host disease secondary to post-bone marrow transplantation rejection. A skin mass with ulceration and exudation was found on his right lower leg one year ago. Ten days ago, skin biopsy and PET-CT in another hospital indicated cutaneous squamous cell carcinoma, so he was admitted to our hospital for tumor resection.

Key words: surgical excision, sclerodermatous chronic graft-versus-host disease, cutaneous squamous cell carcinoma