China Journal of Leprosy and Skin Diseases ›› 2025, Vol. 41 ›› Issue (10): 750-752.doi: 10.12144/zgmfskin202510750

• Case Reports • Previous Articles     Next Articles

Upadacitinib in the treatment of steroid-dependent dermatitis: a case report

ZHU Tingting1,2,3,4, HUANG Hequn1,2,3,4, MA Tongchuan1,2,3,4, ZHU Yueying1,2,3,4, XIAO Fengli1,2,3,4   

  1. 1 Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, Hefei 230032, China; 2 Institute of Dermatology, Anhui Medical University, Hefei 230032, China; 3 Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, Hefei 230032, China; 4 Collaborative Innovation Center of Complex and Severe Skin Disease, Anhui Medical University, Hefei 230032, China
  • Online:2025-10-15 Published:2025-09-29

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Abstract: Steroid-dependent dermatitis is a chronic, recurrent skin condition primarily caused by the prolonged improper use of topical corticosteroids, commonly occurring on the face. In this case, the patient had recurrent facial erythema and itching for 1 year and was diagnosed with steroid-dependent dermatitis. After multiple treatments failed, oral upadacitinib 15 mg/d was administered, and after 4 weeks of treatment, the symptoms significantly improved. Complete resolution was achieved after 8 weeks, with no adverse reactions.

Key words: steroid-induced dermatitis, JAK inhibitor, upadacitinib