Abstract: Castleman disease is a rare hematologic disorder. Two previous cases have been reported abroad in patients with psoriasis complicated by psoriatic arthritis who developed Castleman disease after treatment with TNF-α inhibitors; however, no similar cases have been reported in China to date. In this case, the patient had a 26-year history of psoriasis and a 7-year history of arthritis, and developed Castleman disease after 6 years of treatment with a TNF-α inhibitor. This suggests that such patients should be vigilant about the development of Castleman disease following long-term use of TNF-α inhibitors.

Key words: psoriasis, psoriatic arthritis, Castleman disease, biologics