Abstract: Objectives: To detect the level of TL1A and its receptor DcR3 in the peripheral blood of patients with psoriasis vulgaris. Methods: The level of serum L1A and its receptor DcR3 was detected by enzyme linked immunosorbent assay ( ELISA) in 30 patients with psoriasis vulgaris and 30 healthy controls．Results: The level of serum TL1A and its receptor DcR3 in the patients was 478.21±231.18 pg/mL and 638.31±310.73 pg/mL, which were higher than those in healthy controls （125.67±82.85 pg/mL and 45.16±111.52 pg/mL）(P＜0.05) and those in the patients of progressive stage were 584.91±298.52 pg/mL and 860.41±402.78 pg/mL, which were higher than those in the patients of stable stage （261.73±120.84 pg/mL and 67.34±225.16 pg/mL）（P＜0.05). The level of TL1A in the patients with psoriasis vulgaris was positively correlated with DcR3 (P＜0.05). Conclusion: The level of TL1A and its receptor DcR3 in the peripheral blood of patients with psoriasis vulgaris was significantly increased and TL1A may play important roles in the progress of psoriasis vulgaris by combining with its receptor DcR3.

Key words: psoriasis, TNF-like ligand 1 aberrance, decoy receptor 3