ERAP1基因多态性与银屑病研究进展

Abstract

Abstract: Endoplasmic reticulum aminopeptidase1 (ERAP1) is a gene located in the region of 5q15 with immunologic function. The gene primarily encodes a multifunctional enzyme belonging to the M1 family of aminopeptidases, which plays an important role in the regulation of blood pressure, angiogenesis, shedding of several cytokine receptors in ectodomain and processing of antigenic peptides. ERAP1gene polymorphism is associated with the pathogenesis of psoriasis. The structure and function of ERAP1 and the relation between ERAP1 and psoriasis are reviewed in this paper.

Key words: ERAP1, susceptibility gene, psoriasis

XU Yu, WANG Zaixing, DOU Jinfa, YANG Sen. Update of ERAP1 and psoriasis[J].China Journal of Leprosy and Skin Diseases, 2016, 32(7): 439-441.

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Update of ERAP1 and psoriasis

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