Abstract: The mutations of loss-of-function in the gene of filaggrin (FLG) result in decrease or deficiency of FLG content in epiderma, leading to the change of epidermal barrier function and increasing the risk of atopic dermatitis (AD). The role of FLG in the formation of epidermal barrier, the structure of FLG gene, the mutations in the FLG gene in the patients with AD and the relationship between the clinical phenotype of AD and FLG gene mutations are reviewed in this paper.

Key words: atopic dermatitis, filaggrin, gene mutation, epidermal barrier