辛伐他汀对白癜风氧化应激模型中角质形成细胞趋化因子分泌的影响

Abstract

Abstract:

Objective: To determine the effect of simvastatin on the expression of CXCL9, CXCL10, CXCL11 and CCL22 in H2O2-treated primary human keratinocytes (KC). Methods: KC in the experimental group was pre-treated with different concentration of simvastatin (0.1 μmol/L, 0.5 μmol/L and 1.0 μmol/L), and then, exposed to 1.0 mM H2O2 for 24 h. KC in the H2O2 group was treated with 1.0 mM H2O2 only. The expression levels of mRNA and protein of CXCL9, CXCL10, CXCL11 and CCL22 were detected by Real-time PCR, Western blot and ELISA. Results: The expression levels of mRNA and protein of CXCL9, CXCL10 and CXCL11 in the experimental group were higher than those in H2O2 group, and the level of CCL22 was lower than that in H2O2 group. Conclusion: Simvastatin can influence the levels of CXCL9, CXCL10, CXCL11 and CCL22 through regulating oxidatively stressed KC.

Key words: simvastatin')">

simvastatin, keratinocytes, oxidative stress, chemokine

CHANG Yuqian, LI Shuli, JIAN Zhe, AN Yawen, GAO Tianwen, LI Chunying..

Effects of simvastatin on the expression of chemokine in the keratinocyte under oxidative stress [J].China Journal of Leprosy and Skin Diseases, 2017, 33(2): 79-82.

0
/ / Recommend simvastatin; keratinocytes; oxidative stress; chemokine
”. Please open it by linking:http://www.zgmfskin.com/EN/abstract/abstract253.shtml" name="neirong"> simvastatin; keratinocytes; oxidative stress; chemokine
">

Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks

URL: http://www.zgmfskin.com/EN/

http://www.zgmfskin.com/EN/Y2017/V33/I2/79

[1]	JIANG Hongwei, TIAN Hongqing. Correlation analysis of CCR5, CCR2, SDF1, CXCR4 gene polymorphism and HIV-1 infection in MSM [J]. China Journal of Leprosy and Skin Diseases, 2022, 38(2): 78-82.
[2]	LI Jinzhuo, LIN Zhipeng, ZENG Qianwen, SUN Renshan. Update on the effect of PM2.5 on skin keratinocytes [J]. China Journal of Leprosy and Skin Diseases, 2021, 37(8): 537-542.
[3]	HUANG Shun, YU Yang, WU Xianjie, LIN Qiang. Effect of hemoperfusion on oxidative stress and efficacy in children with abdominal Henoch-Schonlein purpura [J]. China Journal of Leprosy and Skin Diseases, 2021, 37(10): 644-646.
[4]	HAN Yue, YAO Xu. Activation and inflammation of HaCaT Cells regulated by exosomes in peripheral blood of the patients with atopic dermatitis [J]. China Journal of Leprosy and Skin Diseases, 2020, 36(2): 70-74.
[5]	ZHU Jianwei, LUO Dan. Down-regulation of IFN-γ-induced over-expression of surface antigens on normal human keratinocytes by UVB [J]. China Journal of Leprosy and Skin Diseases, 2020, 36(1): 16-19.
[6]	YE Shanshan, LI Yingjie, LI Hui, YAO Xiangjun, WANG Zaixing. The role of Th17 related cytokines and chemokines in pemphigus [J]. China Journal of Leprosy and Skin Diseases, 2019, 35(9): 529-532.
[7]	YAO Qiyu, LUO Yang, YAO Xu, LIU Jun. Effect of linoleic acid on the expression of keratinocytes barrier-associated protein [J]. China Journal of Leprosy and Skin Diseases, 2019, 35(10): 584-586.
[8]	HUANG Dan, JU Mei, CHEN Kun, WU Minzhi, GU Heng. Effect of α-lipoic acid on oxidative stress of keratinocytes induced by UVB [J]. China Journal of Leprosy and Skin Diseases, 2019, 35(1): 1-5.
[9]	WU Yuanyuan, ZHENG Jie, XIAO Fengli. Keratinocytes and atopic dermatitis [J]. China Journal of Leprosy and Skin Diseases, 2019, 35(1): 54-56.
[10]	ZHU Shanshan, Wang Yunlong, PANG Chuanchao. Expression of IL-22 in the lesions of lichen planus [J]. China Journal of Leprosy and Skin Diseases, 2018, 34(7): 418-421.
[11]	JIANG Wei, LI Shuli, LI Chunying.. Update of treatment of vitiligo with statins [J]. China Journal of Leprosy and Skin Diseases, 2018, 34(3): 185-187.
[12]	LI Guishuang, BU Jieqiong, LONG Jianwen. Protective effect of proanthocyanidin on ultraviolet B-induced oxidative damage to HaCaT cells [J]. China Journal of Leprosy and Skin Diseases, 2018, 34(10): 580-584.
[13]	XIAO Qian, CUI Tingting, GAO Tianwen, WANG Lin. . Effects of ginkgo biloba extract EGb761 on anti-oxidation of melanocytes under oxidative stress in vitiligo [J]. China Journal of Leprosy and Skin Diseases, 2017, 33(7): 407-409.
[14]	ZHU Longfei, TIAN Jun, JIAN Zhe, ZHANG Weigang, LIU Bangmin, LI Chunying, GAO Tianwen.. Effects of baicalein on the mitochondrial ultrastructure and function in stressed vitiligo melanocytes [J]. China Journal of Leprosy and Skin Diseases, 2017, 33(6): 321-324.
[15]	BAO Yuting, GUO Zaipei, WANG Xiaoxue, YANG Beichen.. Update of the oxidative stress mechanism of paeoniflorin [J]. China Journal of Leprosy and Skin Diseases, 2017, 33(6): 374-377.

Effects of simvastatin on the expression of chemokine in the keratinocyte under oxidative stress

PDF (PC)

Like

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Metrics

Comments

Recommended 10