Abstract:

Objective:To detect the expression of Raptor, Rictor and p-Akt in the lesions of actinic keratosis (AK), Bowen's disease (BD) and squamous cell carcinoma (SCC). Methods: Immunohistochemistry was used to detect the expression of Raptor, Rictor, p-Akt (Ser473) in the tissue samples from the patients with AK, BD, SCC and normal human skin. Results: The positivity rates of Raptor in SCC, BD and AK were 87.50%, 70.00% and 60.00%, which was significantly higher than that in normal skin (Ps<0.05). The positivity rate was 100% in poorly differentiated squamous cell carcinoma and 75% in well differentiated squamous cell carcinomas, with a significant difference (P<0.05). The positivity rates of Rictor in SCC, BD and AK were 80.00%, 70.00% and 55.00%, which was significantly higher than that in normal skin (P<0.05). The positivity rates of p-Akt (Ser473) in SCC, BD and AK were 77.50%, 65.00% and 50.00%, while there was no positive staining in normal skin. There was a positive correlation between the expression level of Rictor and p-Akt (Ser473) in SCC, BD and AK (P<0.05). Conclusion: The high expression of Raptor, Rictor and p-Akt (Ser473) may play a key role in the occurrence and development of AK, BD and SCC.

Key words: Squamous cell carcinoma')">

Squamous cell carcinoma, Bowen's disease, actinic keratosis, Raptor, Rictor