Abstract: Objective: To determine the characteristics of cognitive function in the patients with psoriasis and the influencing factors. Methods: The cognitive function and emotional states of 43 patients with psoriasis and 30 healthy controls were evaluated with Montreal Cognitive Assessment Scale (MoCA), Beck Depression Inventory-13 (BDI-13) and Beck Anxiety Inventory (BAI). The factors that might influence cognitive function of the patients with psoriasis were analyzed with multivariate regression. Results: The incidence of cognitive dysfunction in the patients with psoriasis was 30.2%. The visuospatial domain scores and executive function scores in the patients with cognitive impairment were 1.69±1.25 and 2.46±0.87, which were lower than those in the patients with normal cognitive (3.03±0.80, 3.33±0.88) and healthy controls (3.30±0.75, 3.57±0.56), with significant differences (P<0.05). Multiple regression analysis showed that age, duration of the disease and BDI score had significantly negative influence on cognitive function in the patients with psoriasis (P＜0.05). Conclusion: The patients with psoriasis have partial cognitive decline and mainly involve the visual space and executive function. The influence factors on cognitive function of the patients with psoriasis include age, duration of the disease and depression. 

Key words: psoriasis, cognitive function, visuospatial domain, executive function