Abstract: The glycosaminoglycan hyaluronic acid (HA) is a major component of extracellular matrix, which has widely been used in clinics. HA has a good?biocompatibility and increases the residence time of other agents.? HA can improve the rehabilitation and reduce the cure time of wound. HA also plays an important role in the barrier therapy and regulating the activity of inflammation. The physicochemical properties, biological properties and the clinical topical application of HA in dermatology are reviewed in this article.

Key words: hyaluronic acid, skin barrier, wound healing, inflammation