Abstract: Laser capture microdissection (LCM) is a new technology that targets cells directly from frozen or paraffin-embedded tissue sections. High-purified of DNA, RNA and protein can be gained through homogenous cells extraction of LCM. LCM technology has been applied in the cell extraction of psoriasis, vitiligo, atopic dermatitis and avoids the disadvantages of traditional cell extraction methods. The principle, process and application of LCM technology in dermatology is reviewed in this paper.

Key words: laser capture microdissection, dermatology, gene expression analysis