Abstract: Tyrosine kinases (TKs) and their receptors play an important role in the growth, adhesion, survival, differentiation, apoptosis, angiogenesis and metastasis of tumor cells. In addition, they are involved in immune regulation, which make them become the important targets of anti-tumor. TK inhibitors (TKIs) have been applied to treatment of dermatofibrosarcoma protuberans, melanoma, mastocytosis, hypereosinophilic syndrome and other skin diseases. The update of the first and second generation TKIs in the treatment of skin diseases is reviewed in this paper.

Key words: tyrosine kinase inhibitor, dermatofibrosarcoma protuberans, melanoma, mastocytosis, hypereosinophilic syndrome