China Journal of Leprosy and Skin Diseases ›› 2025, Vol. 41 ›› Issue (2): 127-129.doi: 10.12144/zgmfskin202502127

• Case Reports • Previous Articles     Next Articles

Generalized pustular psoriasis successfully treated with spesolimab: two cases report

SONG Pingping1,2*, WANG Na1,2*, DU Donghong1,2*, LIU Jing1,2, RAN Delin1,2, YANG Baoqi1,2   

  1. 1 Hospital for Skin Diseases, Shandong First Medical University, Jinan 250022, China; 2 Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan 250022, China *Co-first author
  • Online:2025-02-15 Published:2025-01-22

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Abstract: We report 2 cases of generalized pustular psoriasis(GPP) patients treated with spesolimab. Both patients had poor responses to conventional treatments, and were given a single dose of 900 mg of spesolimab after excluding infectious diseases. The temperature returned to normal on the second day after treatment, and all pustules subsided on the fifth day in one patient. The pustules gradually subsided on the fifth day and the temperature returned to normal on the ninth day in another patient. Neither patient experienced significant adverse reactions during the treatment period.

Key words: generalized pustular psoriasis, spesolimab, therapy