Abstract: Psoriatic arthritis(PsA) can lead to joint deformities in severe cases, affecting patients' daily life. In recent years, domestical and international progress has been made in the pathogenesis of PsA, especially focus on the deep koebner phenomenon triggered by local microtrauma to the joints. The Synovio-Entheseal Complex (SEC) plays an important role in the mechanistic studies of PsA. Due to trauma or mechanical stress, the deep Koebner response occurred at the SEC, activating the innate immune response through the IL-23/Th17 axis, which interacts with the adaptive immune responses, ultimately leading to the development of PsA. This paper reviews the update of mechanical stress related microtrauma in the pathogenesis and development of PsA in recent years both domestically and internationally.

Key words: psoriatic arthritis, the deep Koebner phenomenon, mechanical stress, microtrauma, enthesitis