特应性皮炎的生物学分型及靶向治疗进展

doi:10.12144/zgmfskin201903184

China Journal of Leprosy and Skin Diseases ›› 2019, Vol. 35 ›› Issue (3): 184-188.doi: 10.12144/zgmfskin201903184

Previous Articles Next Articles

Update of atopic dermatitis endotypes and targeted therapies

CHEN Jiawen, YAO Zhirong

Department of Dermatology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China

Online:2019-03-15 Published:2019-04-09
Contact: YAO Zhirong, E-mail: yaozhirong@xinhuamed.com.cn

Abstract

Abstract: Atopic dermatitis (AD), a common chronic inflammatory skin disease, is recognized to be driven by overactive type 2 immune response. Recent studies revealed that the heterogeneity of AD including age of onset, race and intrinsic/extrinsic and different encotypes were indentified. Activation of Th22, Th17/IL-23 and Th1 cytokine pathway varies in different encotypes and the targeted therapies are different accordingly. The update of AD encotypes and the targeted therapies is reviewed.

Key words: atopic dermatitis, encotype, targeted therapy

CHEN Jiawen, YAO Zhirong. Update of atopic dermatitis endotypes and targeted therapies[J].China Journal of Leprosy and Skin Diseases, 2019, 35(3): 184-188.

[1]	HONG Anlan, LIN Tong. Update of the role for TRP channels in inflammatory skin diseases [J]. China Journal of Leprosy and Skin Diseases, 2023, 39(2): 129-133.
[2]	LI Jibing, LI Wei, HU Cui, QIAN Yingying, ZHANG Ting, QIAN Hua. Effects of climatic factors on the outpatient visits of children's atopic dermatitis in Suzhou [J]. China Journal of Leprosy and Skin Diseases, 2023, 39(1): 11-14.
[3]	HUA Sirui, XU Kejia, WANG Lin. Effect of ebastine on Balb/c mouse model of atopic dermatitis [J]. China Journal of Leprosy and Skin Diseases, 2022, 38(6): 355-358.
[4]	CHEN Jing, ZHANG Shoumin. Update of the study of immunological characteristics and management progress in the study of alopecia areata combined with atopic dermatitis [J]. China Journal of Leprosy and Skin Diseases, 2022, 38(5): 343-346.
[5]	LI Mengmeng, LI Jingyi, LIU Qingfeng, LIU Youqing, LI Wei. Clinical efficacy and safety of dupilumab in the treatment of moderate and severe atopic dermatitis for 16 weeks [J]. China Journal of Leprosy and Skin Diseases, 2022, 38(12): 849-852.
[6]	JIANG Fei, ZHAO Qing, SUN Yonghu, ZHANG Zhaoxia, YANG Baoqi, YANG Qing, LIU Guoyan, SHI Zhongxiang, LIU Hong, ZHANG Furen. Efficacy of dupilumab in 5 children with moderate-to-severe atopic dermatitis: a real-world study [J]. China Journal of Leprosy and Skin Diseases, 2022, 38(11): 790-793.
[7]	SHI Aixiu, CAO Shuanglin. Advance of skin adverse reactions caused by molecular targeted anti-tumor drugs [J]. China Journal of Leprosy and Skin Diseases, 2021, 37(9): 605-609.
[8]	WANG Ziwei, LUAN Chao, HU Yu, JU Mei. Advances in the targeted therapy of vitiligo [J]. China Journal of Leprosy and Skin Diseases, 2021, 37(7): 477-480.
[9]	WU Zhe, YAO Zhirong. Update of skin microbiome of common skin diseases in infant [J]. China Journal of Leprosy and Skin Diseases, 2020, 36(3): 185-188.
[10]	HAN Yue, YAO Xu. Activation and inflammation of HaCaT Cells regulated by exosomes in peripheral blood of the patients with atopic dermatitis [J]. China Journal of Leprosy and Skin Diseases, 2020, 36(2): 70-74.
[11]	YANG Yan, CHEN Quan, LIU Yumei, ZHOU Xin, TIAN Xin, GAO Aili, XIONG Siying, CHEN Xiaoyin, LI Wei, ZHU Huilan. Correlation between single nucleotide polymorphisms of IL-33/IL1RL1 genes and atopic dermatitis [J]. China Journal of Leprosy and Skin Diseases, 2020, 36(11): 649-652.
[12]	ZHU Chenxi, YAO Zhirong. Update of the role of langerhans cell in the immune mechanism and treatment in atopic dermatitis [J]. China Journal of Leprosy and Skin Diseases, 2020, 36(10): 631-635.
[13]	CHEN Zhongxiang, SHEN Zhengyu. Correlation between dietary and environmental factors with atopic dermatitis in children [J]. China Journal of Leprosy and Skin Diseases, 2020, 36(1): 53-57.
[14]	HAN Yue, YAO Xu. Bioinformatics analysis of differentially expressed microRNAs in children with atopic dermatitis [J]. China Journal of Leprosy and Skin Diseases, 2019, 35(9): 520-525.
[15]	YUE Wanbo, XU Qianyue, YU Hong. Mastocytosis: pathogenesis and treatment [J]. China Journal of Leprosy and Skin Diseases, 2019, 35(8): 505-508.

Update of atopic dermatitis endotypes and targeted therapies

PDF (PC)

Like

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Metrics

Comments

Recommended 10