中国麻风皮肤病杂志 ›› 2025, Vol. 41 ›› Issue (12): 912-916.doi: 10.12144/zgmfskin202512912

• 综述 • 上一篇    下一篇

瘢痕疙瘩术后复发影响因素研究进展

王松1,廖中海2,秦凤2,李虹2   

  1. 1川北医学院，四川南充，637000；2成都市第二人民医院，四川成都，610000
  • 出版日期:2025-12-15 发布日期:2025-11-28

Research progress on related factors affecting recurrence of keloid after operation

WANG Song1, LIAO Zhonghai2, QIN Feng2, LI Hong2   

  1. 1 North Sichuan Medical College, Nanchong 637000, China; 2 Chengdu Second People's Hospital, Chengdu 610000, China
  • Online:2025-12-15 Published:2025-11-28

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摘要： 瘢痕疙瘩的复发是治疗中的核心难题，单纯手术切除后的复发率高。近年研究提出“表观遗传记忆”假说，即原发病灶切除后，周围微环境仍可激活静息干细胞，导致纤维化进程重启。本综述系统梳理了近年来瘢痕疙瘩复发的影响因素，包括宿主内在因素、疾病相关因素、治疗相关变量及分子机制，并评估现有预防策略的循证医学证据。

关键词: 瘢痕疙瘩, 复发, 影响因素

Abstract: The recurrence of keloid remains a core challenge in treatment, with high recurrence rates following simple surgical excision. Recent research has proposed the “epigenetic memory” hypothesis, suggesting that even after primary lesion removal, the surrounding microenvironment can reactivate quiescent stem cells, leading to a restart of the fibrotic process. This review systematically summarizes recent evidence on factors influencing keloid recurrence, including host intrinsic factors, disease-related factors, treatment-related variables, and molecular mechanisms, and evaluates the evidence base for existing prevention strategies.

Key words: keloid, recurrence, influence factor