中国麻风皮肤病杂志 ›› 2016, Vol. 32 ›› Issue (10): 592-694.

• 论著 • 上一篇    下一篇

评价光动力治疗宫颈高危型人乳头瘤病毒感染的效果

米霞，孙小强，郑和义   

  1. 1.中国人民解放军第306医院皮肤科，北京，100101 2.华北理工大学附属医院皮肤科，河北，063000 3.中国医学科学院北京协和医学院北京协和医院皮肤科，北京，100730
  • 出版日期:2016-10-15 发布日期:2018-12-17
  • 通讯作者: 郑和义，E-mail: zhenghy62@sina.com

Assessment of HPV clearance of photodynamic therapy using 5-aminolaevulinic acid for cervical high risk HPV infection

MI Xia1, SUN Xiaoqiang2, ZHANG Heyi3   

  1. 1. Department of Dermatology, 306 Hospital of the Chinese People's Liberation Army, Beijing 100101, China; 2. Department of Dermatology, Affiliated Hospital of Nouth China University of Science and Technology, Hebei 063000, China; 3. Department of Dermatology, Chinese Academy of Medicine Science, Peking Union Medical College Hospital, Beijing 100730, China
  • Online:2016-10-15 Published:2018-12-17
  • Contact: ZHENG heyi，E-mail: zhenghy62@sina.com

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摘要： 目的：评价5－氨基酮戊酸光动力治疗宫颈高危型人乳头瘤病毒感染的有效性和安全性。方法：将入组的35例宫颈高危型人乳头瘤病毒感染患者随机分为5－氨基酮戊酸光动力治疗组和无治疗的对照组。治疗组每周治疗1次，共3次，治疗结束3个月后复查两组患者宫颈人乳头瘤病毒的转阴率。结果：治疗组17例中10例高危型人乳头瘤病毒转阴，对照组18例中1例转阴，差异有显著性（P<0.05）。治疗组中的副反应包括轻度到中度的疼痛、水肿、糜烂，治疗部位未发生感染、溃疡、瘢痕及畸形。结论：5－氨基酮戊酸光动力可以治疗宫颈高危人乳头瘤病毒感染。

关键词: 5－氨基酮戊酸, 光动力, 人乳头瘤病毒

Abstract: Objective: To assess the HPV clearance and safety of photodynamic therapy using 5-aminolaevulinic acid for cervical high risk human papillomavirus (HR-HPV) infection. Method: Thirty-five patients with cervical HR-HPV infection were divided into topical photodynamic therapy using aminolevulinic acid (ALA-PDT) group （n=17）and control group (n=18). The treatment group were treated once a week for three weeks. Results: After three treatments, the clearance rates were 58.82% (10/17) and 5.6% (1/18) in the treatment group and control group, respectively, with a significant difference (P<0.05). The adverse effects in the treatment group included mild to moderate pain, edema, erosion, without any infection, ulcers, scarring or cervical malformations. Conclusion: ALA-PDT is a safe and effective treatment for cervical HR-HPV infection.

Key words: aminolevulinic acid, photodynamic therapy, human papillomavirus